pan-KRAS-IN-8 (Compound 38) is an inhibitor of the human tumor mutant gene KRAS, inhibiting the proliferation of KRAS mutant cells AsPC-1 (G12D mutant) and SW480 (G12V mutant) with IC50 of 0.07 and 0.18 nM, respectively.

Physicochemical Properties

Molecular Formula	C48H61N7O7S
Molecular Weight	880.11
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. Pan-kras inhibitor compound. WO2024060966A1.

Solubility Data

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	1.1362 mL	5.6811 mL	11.3622 mL
	5 mM	0.2272 mL	1.1362 mL	2.2724 mL
	10 mM	0.1136 mL	0.5681 mL	1.1362 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.