pan-KRAS-IN-15 (compound 58) is a pan-KRAS inhibitor. pan-KRAS-IN-15 can be used in pancreatic cancer research.

Physicochemical Properties

Molecular Formula	C36H37F3N6O2
Molecular Weight	642.71
CAS #	3034052-52-0
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

Targets	K-RAS 1.4 nM (IC50)
ln Vitro	pan-KRAS-IN-15 has a significant inhibitory effect on human pancreatic cancer ASPC-I cells (IC50=1.4 nM)[1].
References	[1]. Kras mutant protein inhibitor, preparation method therefor, and use thereof.WO2024061333A1.2023-09-21https://patents.google.com/patent/WO2024061333A1/en?oq=WO2024061333A1.

Solubility Data

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	1.5559 mL	7.7796 mL	15.5591 mL
	5 mM	0.3112 mL	1.5559 mL	3.1118 mL
	10 mM	0.1556 mL	0.7780 mL	1.5559 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.