pan-KRAS-IN-13 (compound 2) is a potent KRAS inhibitor with IC50 of 2.75 nM and 2.89 nM for G12D and G12V, respectively.

Physicochemical Properties

Molecular Formula	C33H31F3N6O3
Molecular Weight	616.63
CAS #	3033637-76-9
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

Targets	KRas G12D 2.75 nM (IC50); KRas G12V 2.89 nM (IC50)
References	[1]. Ildong Pharmaceutical Co., Ltd. Novel tetraheterocycle compound. World Intellectual Property Organization, WO2024063578 A1 2024-03-28https://patents.google.com/patent/WO2024063578A1/en?oq=WO2024063578A1.

Solubility Data

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	1.6217 mL	8.1086 mL	16.2172 mL
	5 mM	0.3243 mL	1.6217 mL	3.2434 mL
	10 mM	0.1622 mL	0.8109 mL	1.6217 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.