p53 Activator 13 (Compound 11) is a 6mA methyltransferase CamA inhibitor and p53 activator. p53 Activator 13 intercalates into CamA-bound DNA through the minor groove, causing a conformational change that moves the catalytic domain away from the DNA and triggers a DNA damage response through p53 activation. p53 Activator 13 can be used in cancer research.

Physicochemical Properties

Molecular Formula	C33H35N9O
Molecular Weight	573.69
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. Quinoline-based compounds can inhibit diverse enzymes that act on DNA. Cell Chem Biol. 2024 Oct 14:S2451-9456(24)00403-3.

Solubility Data

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	1.7431 mL	8.7155 mL	17.4310 mL
	5 mM	0.3486 mL	1.7431 mL	3.4862 mL
	10 mM	0.1743 mL	0.8716 mL	1.7431 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.