m-PEG1-NHS ester is a PROTAC (PROteolysis TArgeting Chimera) linker based on PEG/Alkyl/ether, which can be used for the synthesis of PROTAC.

Physicochemical Properties

Molecular Formula	C8H11NO5
Molecular Weight	201.177
Exact Mass	201.063
CAS #	1027371-75-0
PubChem CID	23596588
Appearance	White to light yellow solid powder
LogP	-1
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	5
Heavy Atom Count	14
Complexity	247
Defined Atom Stereocenter Count	0
InChi Key	GDPPBYZKFKEXML-UHFFFAOYSA-N
InChi Code	InChI=1S/C8H11NO5/c1-13-5-4-8(12)14-9-6(10)2-3-7(9)11/h2-5H2,1H3
Chemical Name	(2,5-dioxopyrrolidin-1-yl) 3-methoxypropanoate
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

ln Vitro	One ligand is for an E3 ubiquitin ligase, and the other is for the target protein; these two ligands are joined by a linker to form PROTACs. PROTACs target and selectively degrade target proteins by taking advantage of the intracellular ubiquitin-proteasome system.
References	[1]. Lepage ML, et al. Design, synthesis and photochemical properties of the first examples of iminosugar clustersbased on fluorescent cores. Beilstein J Org Chem. 2015 May 6;11:659-67.

Solubility Data

Solubility (In Vitro)	H2O : ~33.33 mg/mL (~165.67 mM)
Solubility (In Vivo)	Solubility in Formulation 1: 100 mg/mL (497.07 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	4.9707 mL	24.8534 mL	49.7067 mL
	5 mM	0.9941 mL	4.9707 mL	9.9413 mL
	10 mM	0.4971 mL	2.4853 mL	4.9707 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.