cis-5-Dodecenoic acid is an endogenously produced metabolite that can inhibit COX-I and COX-II.

Physicochemical Properties

Molecular Formula	C12H22O2
Molecular Weight	198.30188
Exact Mass	198.162
CAS #	2430-94-6
PubChem CID	5312378
Appearance	Colorless to light yellow liquid
Density	0.922g/cm3
Boiling Point	310.6ºC at 760mmHg
Flash Point	207.7ºC
Vapour Pressure	0mmHg at 25°C
Index of Refraction	n20/D 1.454(lit.)
LogP	3.767
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	9
Heavy Atom Count	14
Complexity	162
Defined Atom Stereocenter Count	0
SMILES	C(O)(=O)CCC/C=C/CCCCCC
InChi Key	IJBFSOLHRKELLR-FPLPWBNLSA-N
InChi Code	InChI=1S/C12H22O2/c1-2-3-4-5-6-7-8-9-10-11-12(13)14/h7-8H,2-6,9-11H2,1H3,(H,13,14)/b8-7-
Chemical Name	(Z)-dodec-5-enoic acid
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment (e.g. under nitrogen), avoid exposure to moisture and light.
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References	[1]. Antioxidant and cyclooxygenase activities of fatty acids found in food. J Agric Food Chem. 2002 Apr 10;50(8):2231-4.
Additional Infomation	Cis-5-dodecenoic acid is the cis-stereoisomer of 5-dodecenoic acid. cis-5-Dodecenoic acid has been reported in Aquilaria sinensis with data available.

Solubility Data

Solubility (In Vitro)

DMSO : ~100 mg/mL (~504.29 mM)

Solubility (In Vivo)

Solubility in Formulation 1: ≥ 2.5 mg/mL (12.61 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (12.61 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. Solubility in Formulation 3: ≥ 2.5 mg/mL (12.61 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	5.0429 mL	25.2143 mL	50.4286 mL
	5 mM	1.0086 mL	5.0429 mL	10.0857 mL
	10 mM	0.5043 mL	2.5214 mL	5.0429 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.