c-Fms-IN-2 is an FMS kinase inhibitor (antagonist) with IC50 of 0.024 μM.

Physicochemical Properties

Molecular Formula	C19H21N3O3
Molecular Weight	339.388344526291
Exact Mass	339.158
CAS #	791587-67-2
PubChem CID	9884318
Appearance	Light yellow to yellow solid powder
LogP	2.7
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	4
Heavy Atom Count	25
Complexity	509
Defined Atom Stereocenter Count	0
SMILES	N#CC1=CC=C(C(NC2C(N3CCC(C)CC3)=CC=C(CO)C=2)=O)O1
InChi Key	NNPCFFIJVKYGHR-UHFFFAOYSA-N
InChi Code	InChI=1S/C19H21N3O3/c1-13-6-8-22(9-7-13)17-4-2-14(12-23)10-16(17)21-19(24)18-5-3-15(11-20)25-18/h2-5,10,13,23H,6-9,12H2,1H3,(H,21,24)
Chemical Name	5-cyano-N-[5-(hydroxymethyl)-2-(4-methylpiperidin-1-yl)phenyl]furan-2-carboxamide
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. Discovery of novel FMS kinase inhibitors as anti-inflammatory agents. Bioorg Med Chem Lett. 2008 Mar 1;18(5):1642-8.

Solubility Data

Solubility (In Vitro)

DMSO : ≥ 100 mg/mL (~294.65 mM)

Solubility (In Vivo)

Solubility in Formulation 1: ≥ 2.5 mg/mL (7.37 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	2.9465 mL	14.7323 mL	29.4646 mL
	5 mM	0.5893 mL	2.9465 mL	5.8929 mL
	10 mM	0.2946 mL	1.4732 mL	2.9465 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.