β-N-methylamino-L-alanine HCl (BMAA HCl) is a neurotoxin produced by cyanobacteria that may contribute to amyotrophic lateral sclerosis (ALS) and possibly other neurodegenerative diseases.

Physicochemical Properties

Molecular Formula	C4H11CLN2O2
Molecular Weight	154.60
Exact Mass	154.05
CAS #	16012-55-8
PubChem CID	51358333
Appearance	White to yellow solid powder
LogP	0.51
Hydrogen Bond Donor Count	4
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	3
Heavy Atom Count	9
Complexity	84.1
Defined Atom Stereocenter Count	1
SMILES	CNC[C@@H](C(=O)O)N.Cl
InChi Key	VDXYGASOGLSIDM-DFWYDOINSA-N
InChi Code	InChI=1S/C4H10N2O2.ClH/c1-6-2-3(5)4(7)8;/h3,6H,2,5H2,1H3,(H,7,8);1H/t3-;/m0./s1
Chemical Name	(2S)-2-amino-3-(methylamino)propanoic acid;hydrochloride
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture.
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. The Potential Role of BMAA in Neurodegeneration. Neurotox Res. 2018 Jan; 33(1): 222-226. [2]. BMAA and Neurodegenerative Illness. Neurotox Res. 2018 Jan; 33(1): 178-183. [3]. β-N-methylamino-L-alanine (BMAA) suppresses cell cycle progression of non-neuronal cells. Sci Rep. 2018 Dec 20; 8(1): 17995.

Solubility Data

Solubility (In Vitro)	H2O: 31.25 mg/mL (202.13 mM)
Solubility (In Vivo)	Solubility in Formulation 1: 25 mg/mL (161.71 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	6.4683 mL	32.3415 mL	64.6831 mL
	5 mM	1.2937 mL	6.4683 mL	12.9366 mL
	10 mM	0.6468 mL	3.2342 mL	6.4683 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.