α-Methyltyrosine methyl ester HCl is a competitive inhibitor of tyrosine hydroxylase, which can inhibit the conversion of tyrosine to dopamine and can be used as a research tool on the sympathetic nervous system.

Physicochemical Properties

Molecular Formula	C11H15NO3.HCL
Molecular Weight	245.70264
Exact Mass	245.082
CAS #	7361-31-1
PubChem CID	11957616
Appearance	White to light yellow solid powder
Boiling Point	336.4ºC at 760 mmHg
Melting Point	192 °C (dec.)(lit.)
Flash Point	157.2ºC
LogP	2.327
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	4
Heavy Atom Count	16
Complexity	224
Defined Atom Stereocenter Count	0
SMILES	CC(CC1=CC=C(C=C1)O)(C(=O)OC)N.Cl
InChi Key	OOVDEPZODSXAMU-UHFFFAOYSA-N
InChi Code	InChI=1S/C11H15NO3.ClH/c1-11(12,10(14)15-2)7-8-3-5-9(13)6-4-8;/h3-6,13H,7,12H2,1-2H3;1H
Chemical Name	methyl 2-amino-3-(4-hydroxyphenyl)-2-methylpropanoate;hydrochloride
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture.
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

Solubility Data

Solubility (In Vitro)

H2O : ~25 mg/mL (~101.75 mM) DMSO : ~9.09 mg/mL (~37.00 mM)

Solubility (In Vivo)

Solubility in Formulation 1: ≥ 0.91 mg/mL (3.70 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 9.1 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 0.91 mg/mL (3.70 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 9.1 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. Solubility in Formulation 3: ≥ 0.91 mg/mL (3.70 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 9.1 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	4.0700 mL	20.3500 mL	40.7000 mL
	5 mM	0.8140 mL	4.0700 mL	8.1400 mL
	10 mM	0.4070 mL	2.0350 mL	4.0700 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.