Zofenoprilat is an orally available angiotensin-converting enzyme (ACE) inhibitor with an IC50 of 1.7 nM. Zofenoprilat inhibits the expression of angiotensin II and lowers blood pressure, thereby exerting cardioprotective and renoprotective effects. Zofenoprilat promotes NO production and reduces endothelin-1 (ET-1) expression, which has a protective effect on endothelial function. Zofenoprilat regulates oxidative stress-related molecules and has antioxidant activity.

Physicochemical Properties

Molecular Formula	C15H19NO3S2
Molecular Weight	325.45
CAS #	75176-37-3
Related CAS #	Zofenoprilat-d5;Zofenoprilat arginine;81872-09-5
SMILES	SC[C@H](C(N1CC(SC2C=CC=CC=2)C[C@H]1C(=O)O)=O)C
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. Relative lipophilicities and structural-pharmacological considerations of various angiotensin-converting enzyme (ACE) inhibitors. Pharm Res. 1992 Nov;9(11):1480-6. [2]. Different effects of angiotensin converting enzyme inhibitors on endothelin-1 and nitric oxide balance in human vascular endothelial cells: evidence of an oxidant-sensitive pathway. Mediators Inflamm. 2008;2008:305087.

Solubility Data

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	3.0727 mL	15.3633 mL	30.7267 mL
	5 mM	0.6145 mL	3.0727 mL	6.1453 mL
	10 mM	0.3073 mL	1.5363 mL	3.0727 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.