ZINC20451377 is a small molecule targeting hepatitis B (HBV) surface antigen (HBsAg) and can effectively inhibit wild-type hepatitis B and tenofovir-resistant hepatitis B.

Physicochemical Properties

Molecular Formula	C32H38N4O3
Molecular Weight	526.67
CAS #	2306303-35-3
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. A small molecule targeting hepatitis B surface antigen inhibits clinically relevant drug-resistant hepatitis B virus. J Antimicrob Chemother. 2022 Jul 28;77(8):2120-2124.

Solubility Data

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	1.8987 mL	9.4936 mL	18.9872 mL
	5 mM	0.3797 mL	1.8987 mL	3.7974 mL
	10 mM	0.1899 mL	0.9494 mL	1.8987 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.