ZCL279 is a small molecule modulator (SMM) that inhibits CDC42-intersectin (ITSN) interaction. ZCL279 can activate Cdc42 (a cytoplasmic small GTPase in the Ras superfamily) at lower concentrations (<10 μM) and significantly inhibit it at higher concentrations (<10 μM).

Physicochemical Properties

Molecular Formula	C24H18N2O7S2
Molecular Weight	510.54
CAS #	664975-73-9
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. Enabling Systemic Identification and Functionality Profiling for Cdc42 Homeostatic Modulators. bioRxiv Preprint. 2024 Jan 8:2024.01.05.574351.

Solubility Data

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	1.9587 mL	9.7936 mL	19.5871 mL
	5 mM	0.3917 mL	1.9587 mL	3.9174 mL
	10 mM	0.1959 mL	0.9794 mL	1.9587 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.