Z-DEVD-R110 ((Z-Asp-Glu-Val-Asp)2-Rhodamine 110) is a caspase-3/7 fluorescent substrate. Z-DEVD-R110 can be used to detect apoptosis. Z-DEVD-R110 is a rhodamine derivative with two tetraamino acid (DEVD) peptides linked to fluorophores.

Physicochemical Properties

Molecular Formula	C72H78N10O27
Molecular Weight	1515.44
CAS #	223538-61-2
SMILES	O1C(C2C=CC=CC=2C21C1C=CC(=CC=1OC1C=C(C=CC2=1)NC([C@H](CC(=O)O)NC([C@H](C(C)C)NC([C@H](CCC(=O)O)NC([C@H](CC(=O)O)NC(=O)OCC1C=CC=CC=1)=O)=O)=O)=O)NC([C@H](CC(=O)O)NC([C@H](C(C)C)NC([C@H](CCC(=O)O)NC([C@H](CC(=O)O)NC(=O)OCC1C=CC=CC=1)=O)=O)=O)=O)=O
Synonyms	(Z-Asp-Glu-Val-Asp)₂-Rhodamine 110
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. Apoptosis propagates through the cytoplasm as trigger waves. Science. 2018 Aug 10;361(6402):607-612.

Solubility Data

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	0.6599 mL	3.2994 mL	6.5987 mL
	5 mM	0.1320 mL	0.6599 mL	1.3197 mL
	10 mM	0.0660 mL	0.3299 mL	0.6599 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.