WRN inhibitor 18 (compound 306) is an orally available WRN inhibitor with in vivo anticancer activity.

Physicochemical Properties

Molecular Formula	C35H35F6N5O5S
Molecular Weight	751.74
CAS #	3064599-42-1
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. CHEMICAL COMPOUNDS AND USES THEREOF. WO2024246863.

Solubility Data

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	1.3302 mL	6.6512 mL	13.3025 mL
	5 mM	0.2660 mL	1.3302 mL	2.6605 mL
	10 mM	0.1330 mL	0.6651 mL	1.3302 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.