WRN inhibitor 17 (Compound 250) is an orally active Werner syndrome ATP-dependent helicase (WRN) inhibitor that specifically inhibits the WRN helicase domain activity. WRN inhibitor 17 is expected to be used in cancer research.

Physicochemical Properties

Molecular Formula	C33H34F4N4O6S
Molecular Weight	690.70
CAS #	3064599-40-9
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. CHEMICAL COMPOUNDS AND USES THEREOF. WO2024246863. 2024 December 05.

Solubility Data

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	1.4478 mL	7.2390 mL	14.4781 mL
	5 mM	0.2896 mL	1.4478 mL	2.8956 mL
	10 mM	0.1448 mL	0.7239 mL	1.4478 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.