WRN inhibitor 14 (compound S35) is an oral WRN inhibitor with anticancer activity. WRN inhibitor 14 inhibits tumor growth in the SW48 xenograft model of BALB/c nude mice.

Physicochemical Properties

Molecular Formula	C35H40F4N10O5
Molecular Weight	756.75
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. Design, synthesis, and structure-activity relationship studies of triazolo-pyrimidine derivatives as WRN inhibitors for the treatment of MSI tumors. Eur J Med Chem. 2025 Jan 15;282:117039.

Solubility Data

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	1.3214 mL	6.6072 mL	13.2144 mL
	5 mM	0.2643 mL	1.3214 mL	2.6429 mL
	10 mM	0.1321 mL	0.6607 mL	1.3214 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.