Vomifoliol is a compound related to abscisic acid (ABA) with a modified 2,4-pentadiene side chain and its activity is comparable to that of ABA. Vomifoliol displays antiacetylcholinesterase activity and moderate antileishmanial activity.

Physicochemical Properties

Molecular Formula	C13H20O3
Molecular Weight	224.30
Exact Mass	224.141
CAS #	23526-45-6
PubChem CID	5280462
Appearance	White to off-white solid powder
Density	1.1±0.1 g/cm3
Boiling Point	362.3±42.0 °C at 760 mmHg
Flash Point	187.1±24.4 °C
Vapour Pressure	0.0±1.8 mmHg at 25°C
Index of Refraction	1.567
LogP	1.05
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	2
Heavy Atom Count	16
Complexity	352
Defined Atom Stereocenter Count	2
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: This product requires protection from light (avoid light exposure) during transportation and storage.
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References	[1]. The effect of vomifoliol on stomatal aperture. Planta. 1975;122(3):307-310. [2]. The antiacetylcholinesterase and antileishmanial activities of Canarium patentinervium Miq. Biomed Res Int. 2014;2014:903529.
Additional Infomation	(6S,9R)-vomifoliol is a (6S)-vomifoliol with a R configuration for the hydroxy group at position 9. It has a role as a phytotoxin and a metabolite. It is an enantiomer of a (6R,9S)-vomifoliol. Vomifoliol has been reported in Otanthus maritimus, Euchresta formosana, and other organisms with data available.

Solubility Data

Solubility (In Vitro)

DMSO: 50 mg/mL (222.92 mM)

Solubility (In Vivo)

Solubility in Formulation 1: ≥ 1.25 mg/mL (5.57 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 12.5 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 1.25 mg/mL (5.57 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 12.5 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. Solubility in Formulation 3: ≥ 1.25 mg/mL (5.57 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 12.5 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	4.4583 mL	22.2916 mL	44.5831 mL
	5 mM	0.8917 mL	4.4583 mL	8.9166 mL
	10 mM	0.4458 mL	2.2292 mL	4.4583 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.