Viridicatol is a quinolone alkaloid extracted from fermentation of the endophytic fungus Penicillium spp. of oleander. Viridicatol has strong antifungal activity against Staphylococcus aureus with an MIC of 15.6 μg/mL.

Physicochemical Properties

Molecular Formula	C15H11NO3
Molecular Weight	253.25
Exact Mass	253.074
CAS #	14484-44-7
PubChem CID	115033
Appearance	White to off-white solid powder
LogP	2.606
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	1
Heavy Atom Count	19
Complexity	404
Defined Atom Stereocenter Count	0
InChi Key	QIJIOTTYIGBOQA-UHFFFAOYSA-N
InChi Code	InChI=1S/C15H11NO3/c17-10-5-3-4-9(8-10)13-11-6-1-2-7-12(11)16-15(19)14(13)18/h1-8,17-18H,(H,16,19)
Chemical Name	3-hydroxy-4-(3-hydroxyphenyl)-1H-quinolin-2-one
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References	[1]. A new isoquinolone alkaloid from an endophytic fungus R22 of Nerium indicum. Nat Prod Res. 2017 Apr;31(8):951-958.
Additional Infomation	Viridicatol is a member of quinolines. Viridicatol has been reported in Penicillium cyclopium, Aspergillus versicolor, and Penicillium aurantiogriseum with data available.

Solubility Data

Solubility (In Vitro)

DMSO : 125 mg/mL (493.58 mM)

Solubility (In Vivo)

Solubility in Formulation 1: ≥ 2.08 mg/mL (8.21 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.08 mg/mL (8.21 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	3.9487 mL	19.7433 mL	39.4867 mL
	5 mM	0.7897 mL	3.9487 mL	7.8973 mL
	10 mM	0.3949 mL	1.9743 mL	3.9487 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.