VPC-80051 is an inhibitor of hnRNP A1 splicing activity. VPC-80051 directly interacts with hnRNP A1 RBD and reduces AR-V7 messenger levels in 22Rv1 CRPC cell line. VPC-80051 can be used in prostate cancer research.

Physicochemical Properties

Molecular Formula	C16H13F2N3O
Molecular Weight	301.29
CAS #	2410979-04-1
Related CAS #	VPC-80051 racemate;877969-69-2
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. Computer-Aided Discovery of Small Molecules Targeting the RNA Splicing Activity of hnRNP A1 in Castration-Resistant Prostate Cancer. Molecules. 2019 Feb 20;24(4):763.

Solubility Data

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	3.3191 mL	16.5953 mL	33.1906 mL
	5 mM	0.6638 mL	3.3191 mL	6.6381 mL
	10 mM	0.3319 mL	1.6595 mL	3.3191 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.