VEGFR-2-IN-59 (Compound 3h) is an inhibitor of VEGFR2 with IC50 of 3.73 µM. VEGFR-2-IN-59 exhibits cytotoxicity in cancer cells A549, HT-29, A375, MCF7 and NHDF with IC50 concentrations of 20.91, 19.70, 9.63, 17.43 and 20.71 μM, respectively. VEGFR-2-IN-59 inhibits the formation of tubular structures and exhibits anti-angiogenic properties.

Physicochemical Properties

Molecular Formula	C19H20N6O4
Molecular Weight	396.40
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

Targets	VEGFR2 3.73 μM (IC50)
References	[1]. Synthesis and structural proof of novel oxazolo5,4-dpyrimidine derivatives as potential VEGFR2 inhibitors. In vitro study of their anticancer activity. Bioorg Chem. 2024 Dec;153:107958.

Solubility Data

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	2.5227 mL	12.6135 mL	25.2270 mL
	5 mM	0.5045 mL	2.5227 mL	5.0454 mL
	10 mM	0.2523 mL	1.2614 mL	2.5227 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.