Urotensin II, mouse acetate, is an endogenous ligand of the orphan G protein-coupled receptor GPR14 or SENR. Urotensin II, mouse acetate is a potent vasoconstrictor. plays important roles in the central nervous system.

Physicochemical Properties

Molecular Formula	C??H???N??O??S?
Molecular Weight	1693.91
Related CAS #	Urotensin II, mouse TFA;Urotensin II, mouse
Appearance	White to off-white solid powder
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture.
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

ln Vivo	A cyclic peptide that resembles somatostatin, urotensin II is a modulator of bronchoconstriction, a vasodilator, and an arterial vasocontrictor[1]. In the elevated plus maze test and the hole-board test, urotensin II (0.1 nmol, 0.3 nmol, and 3 nmol; intracerebroventricular injection) dose-dependently causes anxiogenic-like behaviors in mice[1].
Animal Protocol	Animal/Disease Models: Male C57BL/6N mice (8 weeks old)[1] Doses: 0.1 nmol, 0.3 nmol, and 3 nmol Route of Administration: Intracerebroventricular (icv) administration Experimental Results: diminished the amount of head dipping without significant alteration of the motor activity.
References	[1]. Intracerebroventricular administration of urotensin II promotes anxiogenic-like behaviors in rodents. Neurosci Lett. 2004 Mar 25;358(2):99-102.

Solubility Data

Solubility (In Vitro)

May dissolve in DMSO (in most cases), if not, try other solvents such as H2O, Ethanol, or DMF with a minute amount of products to avoid loss of samples

Solubility (In Vivo)

Solubility in Formulation 1: ≥ 2.5 mg/mL (1.48 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (1.48 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	0.5904 mL	2.9518 mL	5.9035 mL
	5 mM	0.1181 mL	0.5904 mL	1.1807 mL
	10 mM	0.0590 mL	0.2952 mL	0.5904 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.