Urotensin II (114-124), human TFA is an 11-amino acid (AA) residue peptide, an orphan receptor GPR14 agonist, and a potent vasoconstrictor.

Physicochemical Properties

Molecular Formula	C66H86F3N13O20S2
Molecular Weight	1502.59
Related CAS #	Urotensin II (114-124), human;251293-28-4
Appearance	Solid powder
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture.
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

Targets	GPR14[1]
ln Vitro	Human Urotensin II (U-II) exhibits a strong affinity for recombinant human GPR14, and this binding is functionally linked to the mobilization of calcium. In a HEK-293 cell line expressing human GPR14 (EC50 = 0:62±0.17 nM, n=6), human urotensin II causes concentration-dependent increases in intracellular calcium[1].
ln Vivo	In anesthetized non-human primates, human urotensin II (U-II) significantly raises total peripheral resistance, a reaction linked to severe heart contractile dysfunction[1].
References	[1]. Human urotensin-II is a potent vasoconstrictor and agonist for the orphan receptor GPR14. Nature. 1999 Sep 16;401(6750):282-6.

Solubility Data

Solubility (In Vitro)	H2O :~100 mg/mL (~66.55 mM)
Solubility (In Vivo)	Solubility in Formulation 1: 100 mg/mL (66.55 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	0.6655 mL	3.3276 mL	6.6552 mL
	5 mM	0.1331 mL	0.6655 mL	1.3310 mL
	10 mM	0.0666 mL	0.3328 mL	0.6655 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.