Physicochemical Properties
| Molecular Formula | C11H8CL2N2O2 |
| Molecular Weight | 271.09 |
| Exact Mass | 269.996 |
| Elemental Analysis | C, 48.74; H, 2.97; Cl, 26.15; N, 10.33; O, 11.80 |
| CAS # | 646530-37-2 |
| Related CAS # | 646530-37-2 |
| PubChem CID | 17173847 |
| Appearance | White to off-white solid powder |
| LogP | 3.615 |
| Hydrogen Bond Donor Count | 1 |
| Hydrogen Bond Acceptor Count | 3 |
| Rotatable Bond Count | 2 |
| Heavy Atom Count | 17 |
| Complexity | 291 |
| Defined Atom Stereocenter Count | 0 |
| SMILES | CC1=CC(=NO1)C(=O)NC2=C(C=C(C=C2)Cl)Cl |
| InChi Key | ULPKSWAQDCJLMN-UHFFFAOYSA-N |
| InChi Code | InChI=1S/C11H8Cl2N2O2/c1-6-4-10(15-17-6)11(16)14-9-3-2-7(12)5-8(9)13/h2-5H,1H3,(H,14,16) |
| Chemical Name | N-(2,4-dichlorophenyl)-5-methyl-1,2-oxazole-3-carboxamide |
| Synonyms | UTL5g; UTL 5g; UTL-5g |
| HS Tariff Code | 2934.99.03.00 |
| Storage |
Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition | Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs) |
Biological Activity
| Targets | TNF-α |
| ln Vitro | RAW 264.7 macrophages are transfected with the appropriate reporter assay plasmids, pretreated with UTL-5g at 1, 10, or 50 µM for 60 min, and then challenged with 100 ng/ml LPS. Transcription factor activity is assessed after a 16-hour incubation. UTL-5g disrupts transcription factors when they exhibit a dose-dependent decline in activity in two experiments. |
| ln Vivo |
UTL-5g (GBL-5g) reduces TGF-β and TNF-α levels that have been raised by lung irradiation[1]. UTL-5g (60 mg/kg; p.o.; daily for 4 days) exhibits beneficial effects in boosting survival rates and lengthening survival times[3]. |
| References |
[1]. UTL-5g Lowers Levels of TGF-β and TNF-α Elevated by Lung Irradiation [2]. Phosphoproteome and transcription factor activity profiling identify actions of the anti-inflammatory agent UTL-5g in LPS stimulated RAW 264.7 cells including disrupting actin remodeling and STAT-3 activation. Eur J Pharmacol. 2017;8 [3]. The small-molecule TNF-α inhibitor, UTL-5g, delays deaths and increases survival rates for mice treated with high doses of cisplatin. Cancer Chemother Pharmacol. 2013;72(3):703-707. |
Solubility Data
| Solubility (In Vitro) |
DMSO: 54~100 mg/mL(199.2~368.9 mM) Ethanol~ ~4 mg/mL(14.8 mM) |
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (9.22 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.6888 mL | 18.4441 mL | 36.8881 mL | |
| 5 mM | 0.7378 mL | 3.6888 mL | 7.3776 mL | |
| 10 mM | 0.3689 mL | 1.8444 mL | 3.6888 mL |