UP163 enhances ATPase activity and activates valosin-containing protein (VCP) with an EC50 of 9.0 μM. UP163 reduces MG-132-induced TDP-43 aggregation.

Physicochemical Properties

Molecular Formula	C20H15CLN2O5S
Molecular Weight	430.86
CAS #	591242-60-3
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. VCP activator reverses nuclear proteostasis defects and enhances TDP-43 aggregate clearance in multisystem proteinopathy models. J Clin Invest. 2024 May 23;134(14):e169039.

Solubility Data

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	2.3209 mL	11.6047 mL	23.2094 mL
	5 mM	0.4642 mL	2.3209 mL	4.6419 mL
	10 mM	0.2321 mL	1.1605 mL	2.3209 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.