UFP-101 TFA is a specific and competitive NOP receptor antagonist (inhibitor) with pKi of 10.24. UFP-101 TFA is >3000-fold selective for delta, mu and kappa opioid receptors. UFP-101 TFA has antidepressant-like effects.

Physicochemical Properties

Molecular Formula	C84H139F3N32O23
Molecular Weight	2022.19
Related CAS #	UFP-101;849024-68-6
Appearance	White to off-white solid powder
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment (e.g. under nitrogen), avoid exposure to moisture and light.
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

ln Vivo	Mice subjected to the forced swimming test (FST) showed a strong immediate and dose-dependent antidepressant-like response when given UFP-101 TFA[1].
References	[1]. [Nphe1,Arg14,Lys15]nociceptin-NH2, a novel potent and selective antagonist of the nociceptin/orphanin FQ receptor. Br J Pharmacol. 2002;136(2):303-311. [2]. Blockade of nociceptin/orphanin FQ-NOP receptor signalling produces antidepressant-like effects: pharmacological and genetic evidences from the mouse forced swimming test. Eur J Neurosci. 2003;17(9):1987-1990.

Solubility Data

Solubility (In Vitro)	H2O :~130 mg/mL (~64.29 mM)
Solubility (In Vivo)	Solubility in Formulation 1: 100 mg/mL (49.45 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	0.4945 mL	2.4726 mL	4.9451 mL
	5 mM	0.0989 mL	0.4945 mL	0.9890 mL
	10 mM	0.0495 mL	0.2473 mL	0.4945 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.