UCB9386 is a brain-penetrant and selective inhibitor of Nuak1 with a pIC50 of 10.1. UCB9386 inhibits Nuak2 and Kak2 with approximately 50% inhibition at 10 nM.

Physicochemical Properties

Molecular Formula	C27H26N8O
Molecular Weight	478.55
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. Discovery of UCB9386: A Potent, Selective, and Brain-Penetrant Nuak1 Inhibitor Suitable for In Vivo Pharmacological Studies. J Med Chem. 2024 Dec 12;67(23):20879-20910.

Solubility Data

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	2.0896 mL	10.4482 mL	20.8965 mL
	5 mM	0.4179 mL	2.0896 mL	4.1793 mL
	10 mM	0.2090 mL	1.0448 mL	2.0896 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.