Tubulin polymerization-IN-74 (compound 11) is a tubulin polymerization inhibitor with IC50 of 15 μM. Tubulin polymerization-IN-74 can be used in anticancer research.

Physicochemical Properties

Molecular Formula	C14H11NS
Molecular Weight	225.31
CAS #	54491-43-9
SMILES	C1(SC2C3C(=CC=CC=3)NC=2)C=CC=CC=1
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. Arylthioindoles, potent inhibitors of tubulin polymerization. J Med Chem. 2004 Dec 2;47(25):6120-3.

Solubility Data

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	4.4383 mL	22.1916 mL	44.3833 mL
	5 mM	0.8877 mL	4.4383 mL	8.8767 mL
	10 mM	0.4438 mL	2.2192 mL	4.4383 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.