Tubulin inhibitor 49 (Compound 18) is a tubulin polymerization inhibitor with IC50 of 48 μM. Tubulin inhibitor 49 can disrupt the cellular microtubule network, arrest the cell cycle at the G2 phase, and exhibit cytotoxicity (IC50=8.8 μM in HeLa cells).

Physicochemical Properties

Molecular Formula	C18H14F3N3OS
Molecular Weight	377.38
CAS #	1023875-75-3
SMILES	S1C=C(C2C=CC(=CC=2)NC(C)=O)N=C1NC1=CC=CC(C(F)(F)F)=C1
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. Rational Design of a Novel Tubulin Inhibitor with a Unique Mechanism of Action. Angew Chem Int Ed Engl. 2022 Jun 20;61(25):e202204052.

Solubility Data

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	2.6498 mL	13.2492 mL	26.4985 mL
	5 mM	0.5300 mL	2.6498 mL	5.2997 mL
	10 mM	0.2650 mL	1.3249 mL	2.6498 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.