Tryptamine HCl belongs to the indole alkaloids and is an analogue of the amino acid (AA) tryptophan. Tryptamine HCl is psychoactive and works as a neurotransmitter in the body, affecting mood, perception and cognition. In its HCl form, Tryptamine HCl, it is extensively used as a starting material for research chemicals and the synthesis of other organic/chemical reagents. It can also occur naturally in certain plants and animals such as fungi and mammals. Due to the psychoactive properties of Tryptamine HCl and its analogues, its use and possession are controlled substances in many countries.

Physicochemical Properties

Molecular Formula	C10H13CLN2
Molecular Weight	196.68
Exact Mass	196.076
CAS #	343-94-2
Related CAS #	Tryptamine;61-54-1;Tryptamine-d2 hydrochloride;362049-48-7
PubChem CID	67652
Appearance	White to off-white solid powder
Density	1.157g/cm3
Boiling Point	378.8ºC at 760mmHg
Melting Point	253-255 °C(lit.)
Flash Point	187.7ºC
LogP	3.171
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	1
Rotatable Bond Count	2
Heavy Atom Count	13
Complexity	147
Defined Atom Stereocenter Count	0
SMILES	Cl[H].N1([H])C([H])=C(C([H])([H])C([H])([H])N([H])[H])C2=C([H])C([H])=C([H])C([H])=C12
InChi Key	KDFBGNBTTMPNIG-UHFFFAOYSA-N
InChi Code	InChI=1S/C10H12N2.ClH/c11-6-5-8-7-12-10-4-2-1-3-9(8)10;/h1-4,7,12H,5-6,11H2;1H
Chemical Name	2-(1H-indol-3-yl)ethanamine;hydrochloride
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

ln Vitro

In study pertaining to life sciences, tryptamine (hydrochloride) is a biochemical reagent that can be utilized as an organic substance or biological material.

Solubility Data

Solubility (In Vitro)

DMSO: 100 mg/mL (508.44 mM)

Solubility (In Vivo)

Solubility in Formulation 1: ≥ 2.5 mg/mL (12.71 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (12.71 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. Solubility in Formulation 3: ≥ 2.5 mg/mL (12.71 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	5.0844 mL	25.4220 mL	50.8440 mL
	5 mM	1.0169 mL	5.0844 mL	10.1688 mL
	10 mM	0.5084 mL	2.5422 mL	5.0844 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.