Triphenyl phosphate is an organophosphate flame retardant. Triphenyl phosphate can disrupt placental tryptophan metabolism by activating MAOA/ROS/NFκB, inducing abnormal neurobehavior. Triphenyl phosphate promotes inflammatory factors such as nuclear factor κ B (NFκB), interleukin-6, and tumor necrosis factor α to induce oxidative stress. Triphenyl phosphate can cause allergic contact dermatitis.

Physicochemical Properties

Molecular Formula	C18H15O4P
Molecular Weight	326.28
CAS #	115-86-6
Related CAS #	Triphenyl phosphate-d15;1173020-30-8
Appearance	White to off-white solid powder
SMILES	P(=O)(OC1C=CC=CC=1)(OC1C=CC=CC=1)OC1C=CC=CC=1
Synonyms	Triphenyl phosphate
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

Targets	IL-6
References	[1]. Triphenyl phosphate disrupts placental tryptophan metabolism by activating MAOA/ROS/NFκB. Sci Total Environ. 2023 Dec 15:904:166688. [2]. Allergic contact dermatitis from triphenyl phosphate. Contact Dermatitis. 1992 Apr;26(4):264-5.

Solubility Data

Solubility (In Vitro)

DMSO : ~100 mg/mL (~306.49 mM; with ultrasonication)

Solubility (In Vivo)

Solubility in Formulation 1: ≥ 5 mg/mL (15.32 mM)(saturation unknown) in 10% DMSO 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one),clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 50.0 mg/mL clear DMSO stock solution and add it to 900 μL of 20% SBE-β-CD saline solution and mix well. 2 g SBE-β-CD (sulfobutyl ether β-cyclodextrin) powder is diluted to 10 mL of saline and completely dissolved until clear and transparent. Solubility in Formulation 2: ≥ 5 mg/mL (15.32 mM)(saturation unknown) in 10% DMSO 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one),clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 50.0 mg/mL clear DMSO stock solution and add it to 900 μL corn oil and mix well.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	3.0649 mL	15.3243 mL	30.6485 mL
	5 mM	0.6130 mL	3.0649 mL	6.1297 mL
	10 mM	0.3065 mL	1.5324 mL	3.0649 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.