Triapine (hydrochloride) is the hydrochloride form of Triapine. Triapine (3-AP; PAN-811) is a ribonucleotide reductase (RR) M2 subunit inhibitor and a potent radiosensitizer.

Physicochemical Properties

Molecular Formula	C7H10CLN5S
Molecular Weight	231.71
CAS #	216240-62-9
Related CAS #	Triapine,(E)-3-AP
Synonyms	3-AP hydrochloride; PAN-811 hydrochloride; OCX191 hydrochloride
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. A dose escalation and pharmacodynamic study of Triapine and radiation in patients with locally advanced pancreas cancer. Int J Radiat Oncol Biol Phys. 2012 Nov 15;84(4):e475-81.

Solubility Data

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	4.3157 mL	21.5787 mL	43.1574 mL
	5 mM	0.8631 mL	4.3157 mL	8.6315 mL
	10 mM	0.4316 mL	2.1579 mL	4.3157 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.