Topoisomerase inhibitor 5 (compound 158) is a bacterial topoisomerase inhibitor with a minimum inhibitory concentration of 0.125 μg/mL. Topoisomerase inhibitor has anti-tuberculosis activity.

Physicochemical Properties

Molecular Formula	C24H25FN4O6
Molecular Weight	484.48
CAS #	2758889-92-6
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. Anti-Mycobacterial Activity of Bacterial Topoisomerase Inhibitors with Dioxygenated Linkers. ACS Infect Dis. 2025 Jan 10.

Solubility Data

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	2.0641 mL	10.3203 mL	20.6407 mL
	5 mM	0.4128 mL	2.0641 mL	4.1281 mL
	10 mM	0.2064 mL	1.0320 mL	2.0641 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.