Topoisomerase II inhibitor 20 TFA is a potent topoisomerase II inhibitor with IC50 of 0.98 µM. Topoisomerase II inhibitor 20 TFA can induce apoptosis and has broad-spectrum anticancer activity.

Physicochemical Properties

Molecular Formula	C24H24F5N5O4S
Molecular Weight	573.54
Related CAS #	Topoisomerase II inhibitor 20
Appearance	Solid powder
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture.
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

Targets	Topoisomerase II 0.98 μM (IC50)
References	[1]. Design, synthesis and in vitro anticancer activity of some new lomefloxacin derivatives. Sci Rep. 2024 Mar 14;14(1):6175https://pubmed.ncbi.nlm.nih.gov/38485748/.

Solubility Data

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	1.7436 mL	8.7178 mL	17.4356 mL
	5 mM	0.3487 mL	1.7436 mL	3.4871 mL
	10 mM	0.1744 mL	0.8718 mL	1.7436 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.