Tiliquinol (NSC 130828) is a non-absorbable antiamoebic agent. Tiliquinol is widely utilized in combination with tibroquinol. Tiliquinol may be utilized in the study of amoebic liver abscesses.

Physicochemical Properties

Molecular Formula	C10H9NO
Molecular Weight	159.19
Exact Mass	159.068
CAS #	5541-67-3
PubChem CID	71208
Appearance	Typically exists as solid at room temperature
Density	1.2±0.1 g/cm3
Boiling Point	324.7±22.0 °C at 760 mmHg
Melting Point	122-124°C
Flash Point	150.2±22.3 °C
Vapour Pressure	0.0±0.7 mmHg at 25°C
Index of Refraction	1.666
LogP	2.33
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	0
Heavy Atom Count	12
Complexity	160
Defined Atom Stereocenter Count	0
SMILES	OC1=C2N=CC=CC2=C(C)C=C1
InChi Key	RPVGLMKJGQMQSN-UHFFFAOYSA-N
InChi Code	InChI=1S/C10H9NO/c1-7-4-5-9(12)10-8(7)3-2-6-11-10/h2-6,12H,1H3
Chemical Name	5-methylquinolin-8-ol
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References	[1]. Nespola B, et al. First case of amebic liver abscess 22 years after the first occurrence. Parasite. 2015;22:20. [2]. Desoubeaux G, et al. Unusual multiple large abscesses of the liver: interest of the radiological features and the real-time PCR to distinguish between bacterial and amebic etiologies. Pathog Glob Health. 2014;108(1):53-57.
Additional Infomation	Tiliquinol is a hydroxyquinoline. Tiliquinol is an antiprotozoal agent that was used in combination with tibroquinol. The combination agent was withdrawn from the market because of hepatoxicity.

Solubility Data

Solubility (In Vitro)

DMSO : 100 mg/mL (628.18 mM)

Solubility (In Vivo)

Solubility in Formulation 1: ≥ 2.5 mg/mL (15.70 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: 2.5 mg/mL (15.70 mM) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), suspension solution; with ultrasonication. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	6.2818 mL	31.4090 mL	62.8180 mL
	5 mM	1.2564 mL	6.2818 mL	12.5636 mL
	10 mM	0.6282 mL	3.1409 mL	6.2818 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.