Tetradecanedioic acid is an endogenously produced metabolite and is a long-chain fatty acid organic/chemical reagent. Tetradecanedioic acid may serve as a candidate biomarker for active molecule-active molecule interactions mediated by organic anion transporting peptides.

Physicochemical Properties

Molecular Formula	C14H26O4
Molecular Weight	258.3538
Exact Mass	258.183
CAS #	821-38-5
Related CAS #	Tetradecanedioic acid-d24;130348-88-8
PubChem CID	13185
Appearance	White to off-white solid powder
Density	1.0±0.1 g/cm3
Boiling Point	434.1±18.0 °C at 760 mmHg
Melting Point	124-127 °C(lit.)
Flash Point	230.5±17.7 °C
Vapour Pressure	0.0±2.2 mmHg at 25°C
Index of Refraction	1.475
LogP	3.99
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	13
Heavy Atom Count	18
Complexity	202
Defined Atom Stereocenter Count	0
InChi Key	HQHCYKULIHKCEB-UHFFFAOYSA-N
InChi Code	InChI=1S/C14H26O4/c15-13(16)11-9-7-5-3-1-2-4-6-8-10-12-14(17)18/h1-12H2,(H,15,16)(H,17,18)
Chemical Name	tetradecanedioic acid
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. LC-MS/MS bioanalysis of plasma 1, 14-tetradecanedioic acid and 1, 16-hexadecanedioic acid as candidate biomarkers for organic anion-transporting polypeptide mediated drug-drug interactions. Bioanalysis. 2018 Sep 1;10(18):1473-1485.

Additional Infomation

Tetradecanedioic acid is an alpha,omega-dicarboxylic acid that is tetradecane in which the methyl groups have been oxidised to the corresponding carboxylic acids. It has a role as a human metabolite. It is an alpha,omega-dicarboxylic acid and a dicarboxylic fatty acid. It is a conjugate acid of a tetradecanedioate(2-). It derives from a hydride of a tetradecane. Tetradecanedioic acid has been reported in Drosophila melanogaster, Arabidopsis thaliana, and Pinus radiata with data available.

Solubility Data

Solubility (In Vitro)

DMSO : ~50 mg/mL (~193.53 mM)

Solubility (In Vivo)

Solubility in Formulation 1: 2.5 mg/mL (9.68 mM) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), suspension solution; with sonication. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (9.68 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	3.8707 mL	19.3536 mL	38.7072 mL
	5 mM	0.7741 mL	3.8707 mL	7.7414 mL
	10 mM	0.3871 mL	1.9354 mL	3.8707 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.