Teclozan (WIN 13146) is an antiprotozoal agent belonging to the benzylamine analogues class. Teclozan interferes with phospholipid metabolism and prevents the formation of arachidonic acid. Teclozan acts in the intestinal lumen and is effective against G. intestinalis. Teclozan may be utilized in the study of protozoan infections.

Physicochemical Properties

Molecular Formula	C20H28CL4N2O4
Molecular Weight	502.26
Exact Mass	500.08
Elemental Analysis	C, 47.83; H, 5.62; Cl, 28.23; N, 5.58; O, 12.74
CAS #	5560-78-1
PubChem CID	21723
Appearance	Solid powder
Density	1.294g/cm3
Boiling Point	585.8ºC at 760mmHg
Flash Point	308.1ºC
Index of Refraction	1.541
LogP	4.024
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	14
Heavy Atom Count	30
Complexity	459
Defined Atom Stereocenter Count	0
SMILES	CCOCCN(CC1=CC=C(C=C1)CN(CCOCC)C(=O)C(Cl)Cl)C(=O)C(Cl)Cl
InChi Key	MSJLJWCAEPENBL-UHFFFAOYSA-N
InChi Code	InChI=1S/C20H28Cl4N2O4/c1-3-29-11-9-25(19(27)17(21)22)13-15-5-7-16(8-6-15)14-26(10-12-30-4-2)20(28)18(23)24/h5-8,17-18H,3-4,9-14H2,1-2H3
Chemical Name	Acetamide, N,N'-(1,4-phenylenebis(methylene))bis(2,2-dichloro-N-(2-ethoxyethyl)-
Synonyms	Teclozan; Falmonox; Teclosine; Teclozine; NSC 107433; Teclosan; Teclosine; Win 13146; Win-13146; Win13146; Win-AM 13146;
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: This product requires protection from light (avoid light exposure) during transportation and storage.
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References	[1]. Gonzales MLM, et al. Antiamoebic drugs for treating amoebic colitis. Cochrane Database Syst Rev. 2019;1(1):CD006085. Published 2019 Jan 9. [2]. Díaz, V. M. M. . Pharmacological Treatment of Giardiasis. In: Rodriguez-Morales, A. J. , editor. Current Topics in Giardiasis [Internet]. London: IntechOpen; 2017.
Additional Infomation	Teclozan is a member of benzenes. Teclozan is an antiprotozoal agent employed typically as a therapy to treat protozoan infections.

Solubility Data

Solubility (In Vitro)

DMSO : 62.5 mg/mL (124.44 mM)

Solubility (In Vivo)

Solubility in Formulation 1: ≥ 2.08 mg/mL (4.14 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	1.9910 mL	9.9550 mL	19.9100 mL
	5 mM	0.3982 mL	1.9910 mL	3.9820 mL
	10 mM	0.1991 mL	0.9955 mL	1.9910 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.