Taraxasterol is a pentacyclic triterpenoid extracted from Taraxacum mongolicum. Taraxasterol has metabolite and anti~inflammatory effects.

Physicochemical Properties

Molecular Formula	C30H50O
Molecular Weight	426.7174
Exact Mass	426.386
CAS #	1059-14-9
PubChem CID	610148
Appearance	White to off-white solid powder
Density	1.0±0.1 g/cm3
Boiling Point	488.2±14.0 °C at 760 mmHg
Melting Point	221-222°
Flash Point	217.0±12.4 °C
Vapour Pressure	0.0±2.8 mmHg at 25°C
Index of Refraction	1.534
LogP	11.06
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	1
Rotatable Bond Count	0
Heavy Atom Count	31
Complexity	766
Defined Atom Stereocenter Count	0
InChi Key	XWMMEBCFHUKHEX-UHFFFAOYSA-N
InChi Code	InChI=1S/C30H50O/c1-19-11-14-27(5)17-18-29(7)21(25(27)20(19)2)9-10-23-28(6)15-13-24(31)26(3,4)22(28)12-16-30(23,29)8/h20-25,31H,1,9-18H2,2-8H3
Chemical Name	4,4,6a,6b,8a,12,14b-heptamethyl-11-methylidene-1,2,3,4a,5,6,6a,7,8,9,10,12,12a,13,14,14a-hexadecahydropicen-3-ol
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: This product requires protection from light (avoid light exposure) during transportation and storage.
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. Effects of taraxasterol on inflammatory responses in lipopolysaccharide-induced RAW 264.7 macrophages. J Ethnopharmacol. 2012 May 7;141(1):206-11. [2]. Sang R, Yu Y, Ge B, Xu L, Wang Z, Zhang X. Taraxasterol from Taraxacum prevents concanavalin A-induced acute hepatic injury in mice via modulating TLRs/NF-κB and Bax/Bc1-2 signalling pathways. Artif Cells Nanomed Biotechnol. 2019;47(1):3929-3937. [3]. Anti-inflammatory effects of taraxasterol on LPS-stimulated human umbilical vein endothelial cells. Inflammation, 2018, 41: 1755-1761. [4]. Protective effect of taraxasterol on acute lung injury induced by lipopolysaccharide in mice. International Immunopharmacology, 2014, 19(2): 342-350.

Additional Infomation

Taraxasterin has been reported in Balanophora japonica, Cota palaestina, and other organisms with data available. See also: Taraxasterol (annotation moved to).

Solubility Data

Solubility (In Vitro)

Ethanol : ~5.5 mg/mL (~12.89 mM ) DMSO : ~1 mg/mL (~2.34 mM)

Solubility (In Vivo)

Solubility in Formulation 1: ≥ 0.55 mg/mL (1.29 mM) (saturation unknown) in 10% EtOH + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 5.5 mg/mL clear EtOH stock solution to 400 μL of PEG300 and mix evenly; then add 50 μL of Tween-80 to the above solution and mix evenly; then add 450 μL of normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 0.55 mg/mL (1.29 mM) (saturation unknown) in 10% EtOH + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 5.5 mg/mL clear EtOH stock solution to 900 μL of corn oil and mix well.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	2.3435 mL	11.7173 mL	23.4346 mL
	5 mM	0.4687 mL	2.3435 mL	4.6869 mL
	10 mM	0.2343 mL	1.1717 mL	2.3435 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.