Tandutinib (MLN518) sulfate is a potent and selective inhibitor of FLT3 with IC50 of 0.22 μM, and also inhibits c-Kit and PDGFR with IC50 of 0.17 μM and 0.20 μM, respectively. Tandutinib sulfate can be used in acute myeloid leukemia and has the ability to cross the blood-brain barrier.

Physicochemical Properties

Molecular Formula	C31H44N6O8S
Molecular Weight	660.78
CAS #	387867-14-3
Related CAS #	Tandutinib;387867-13-2
SMILES	S(O)(O)(=O)=O.O(C1C(=CC2N=CN=C(N3CCN(C(=O)NC4C=CC(OC(C)C)=CC=4)CC3)C=2C=1)OCCCN1CCCCC1)C
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. CT53518, a novel selective FLT3 antagonist for the treatment of acute myelogenous leukemia (AML). Cancer Cell, 2002, 1(5), 421-432. [2]. Effects of MLN518, a dual FLT3 and KIT inhibitor, on normal and malignant hematopoiesis. Blood, 2004, 104(9), 2912-2918. [3]. P-glycoprotein and breast cancer resistance protein affect disposition of tandutinib, a tyrosine kinase inhibitor. Drug Metab Lett. 2010 Dec;4(4):201-12.

Solubility Data

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	1.5134 mL	7.5668 mL	15.1336 mL
	5 mM	0.3027 mL	1.5134 mL	3.0267 mL
	10 mM	0.1513 mL	0.7567 mL	1.5134 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.