TMX-3013 is a CDKs inhibitor that can inhibit the activity of CDK1, CDK2, CDK4, CDK5, and CDK6, with IC50 values of 0.9 nM, <0.5 nM, 24.5 nM, 0.5 nM, and 15.6 nM, respectively. TMX-3013 can be used to synthesize PROTACs with polyethylene glycol (PEG) as a linker and Thalidomide as a CRBN-recruitment arm.

Physicochemical Properties

Molecular Formula	C17H14BRFN6O3S
Molecular Weight	481.30
CAS #	2488761-18-6
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

Targets	CDK1 0.9 nM (IC50); CDK2 <0.5 nM (IC50); CDK4 24.5 nM (IC50); CDK5 0.5 nM (IC50); CDK6 15.6 nM (IC50)
References	[1]. Development of CDK2 and CDK5 dual degrader TMX‐2172J. Angewandte Chemie, 2020, 132(33): 13969-13974.

Solubility Data

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	2.0777 mL	10.3885 mL	20.7771 mL
	5 mM	0.4155 mL	2.0777 mL	4.1554 mL
	10 mM	0.2078 mL	1.0389 mL	2.0777 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.