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TDI-015051 is an orally available inhibitor of SARS-CoV-2 nonstructural protein 14 (SARS-CoV-2 NSP14) with an IC50 of ≤0.15 nM. TDI-015051 inhibits SARS-CoV-2 NSP14 in Huh-7.5 cells (EC50=11.4 nM) and A549 cells expressing ACE2-TMPRSS2 (EC50=64.7 nM). TDI-015051 also inhibits other coronaviruses such as α-hCoV-NL63, α-hCoV-229E, and β-hCoV-MERS with IC50 of 1.7, 2.6, and 3.6 nM, respectively. TDI-015051 inhibits viral RNA methylation and viral replication by binding to the SAH-stabilized cap pocket and exhibits anti-infective activity in mouse models.
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Physicochemical Properties
| Molecular Formula |
C22H22FN5O4S
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| Molecular Weight |
471.50
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| CAS # |
3052313-73-9
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| Storage |
Powder-20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
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| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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Biological Activity
| References |
[1]. Small-molecule inhibition of SARS-CoV-2 NSP14 RNA cap methyltransferase. Nature. 2024 Dec 11.
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Solubility Data
| Preparing Stock Solutions |
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1 mg |
5 mg |
10 mg |
| 1 mM |
2.1209 mL |
10.6045 mL |
21.2089 mL |
| 5 mM |
0.4242 mL |
2.1209 mL |
4.2418 mL |
| 10 mM |
0.2121 mL |
1.0604 mL |
2.1209 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles. |
