Sultopride HCl (LIN-1418 HCl) is a selective antagonist of dopamine D2 receptors.

Physicochemical Properties

Molecular Formula	C17H27CLN2O4S
Molecular Weight	390.92
Exact Mass	390.138
CAS #	23694-17-9
Related CAS #	Sultopride;53583-79-2
PubChem CID	3082221
Appearance	Typically exists as solid at room temperature
Density	1.16g/cm3
Boiling Point	530ºC
Melting Point	181-182ºC
Vapour Pressure	2.57E-11mmHg at 25°C
LogP	3.914
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	7
Heavy Atom Count	25
Complexity	517
Defined Atom Stereocenter Count	0
SMILES	O=C(NCC1N(CC)CCC1)C2=CC(S(=O)(CC)=O)=CC=C2OC.Cl
InChi Key	IGOWMQPOGQYFFM-UHFFFAOYSA-N
InChi Code	InChI=1S/C17H26N2O4S.ClH/c1-4-19-10-6-7-13(19)12-18-17(20)15-11-14(24(21,22)5-2)8-9-16(15)23-3/h8-9,11,13H,4-7,10,12H2,1-3H3,(H,18,20)1H
Chemical Name	N-((1-Ethylpyrrolidin-2-yl)methyl)-5-(ethylsulfonyl)-2-methoxybenzamide hydrochloride
Synonyms	Sultopride Hydrochloride Sultopride HCl
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture.
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

ln Vivo	Sultopride Hydrochloride (LIN-1418 HydroHClide) is a selective antagonist of dopamine D2 receptors. Rats treated with both sultopride hydrochloride and sulpiride showed higher levels of DOPAC and HVA in the striatum, nucleus accumbens, and medial prefrontal cortex when compared to controls. In the striatum, sulpiride hydrochloride-treated rats had higher levels of DOPAC and HVA than sulpiride-treated rats (p<0.05). In the nucleus accumbens, sulpiride hydrochloride-treated rats had higher DOPAC and HVA levels than sulpiride-treated rats (p<0.05). In rats treated with sultopride hydrochloride and sulpiride, DOPAC and HVA levels were higher in the striatum or nucleus accumbens than in the medial prefrontal cortex (p<0.05) [1].
References	[1]. Moriuchi K, et al. Differences in effects of sultopride and sulpiride on dopamine turnover in rat brain. Neurochem Res. 1995 Jan;20(1):95-9
Additional Infomation	A benzamide derivative that is used as an antipsychotic agent for the treatment of schizophrenia. It is also used as an antidepressive agent.

Solubility Data

Solubility (In Vitro)	DMSO : ~50 mg/mL (~127.90 mM) H2O : ~50 mg/mL (~127.90 mM)
Solubility (In Vivo)	Solubility in Formulation 1: 140 mg/mL (358.12 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	2.5581 mL	12.7903 mL	25.5807 mL
	5 mM	0.5116 mL	2.5581 mL	5.1161 mL
	10 mM	0.2558 mL	1.2790 mL	2.5581 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.