Physicochemical Properties
| Molecular Formula | C9H8N3NAO2S2 |
| Molecular Weight | 277.3 |
| Exact Mass | 276.995 |
| CAS # | 144-74-1 |
| Related CAS # | Sulfathiazole;72-14-0;Sulfathiazole-d4;1020719-89-4 |
| PubChem CID | 12285822 |
| Appearance | White to off-white solid powder |
| Boiling Point | 479.5ºC at 760mmHg |
| Melting Point | 175ºC (form a); 202ºC (form b) |
| Flash Point | 243.8ºC |
| Vapour Pressure | 2.35E-09mmHg at 25°C |
| LogP | 3.046 |
| Hydrogen Bond Donor Count | 1 |
| Hydrogen Bond Acceptor Count | 6 |
| Rotatable Bond Count | 3 |
| Heavy Atom Count | 17 |
| Complexity | 326 |
| Defined Atom Stereocenter Count | 0 |
| SMILES | O=S(C1=CC=C(N)C=C1)([N-]C2=NC=CS2)=O.[Na+] |
| InChi Key | GWIJGCIVKLITQK-UHFFFAOYSA-N |
| InChi Code | InChI=1S/C9H8N3O2S2.Na/c10-7-1-3-8(4-2-7)16(13,14)12-9-11-5-6-15-9;/h1-6H,10H2;/q-1;+1 |
| Chemical Name | sodium;(4-aminophenyl)sulfonyl-(1,3-thiazol-2-yl)azanide |
| HS Tariff Code | 2934.99.9001 |
| Storage |
Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture. |
| Shipping Condition | Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs) |
Biological Activity
| References |
[1]. Perez, S., P. Eichhorn, and D.S. Aga, Evaluating the biodegradability of sulfamethazine, sulfamethoxazole, sulfathiazole, and trimethoprim at different stages of sewage treatment. Environ Toxicol Chem, 2005. 24(6): p. 1361-7. [2]. Quantification of veterinary antibiotics (sulfonamides and trimethoprim) in animal manure by liquid chromatography-mass spectrometry. J Chromatogr A, 2002. 952(1-2): p. 111-20. [3]. Kahle, M. and C. Stamm, Time and pH-dependent sorption of the veterinary antimicrobial sulfathiazole to clay minerals and ferrihydrite. Chemosphere, 2007. 68(7): p. 1224-31. |
| Additional Infomation |
Sulfathiazole sodium is a sulfonamide. A sulfathiazole compound that is used as a short-acting anti-infective agent. It is no longer commonly used systemically due to its toxicity, but may still be applied topically in combination with other drugs for the treatment of vaginal and skin infections, and is still used in veterinary medicine. |
Solubility Data
| Solubility (In Vitro) |
DMSO : ~140 mg/mL (~504.87 mM) H2O : ~140 mg/mL (~504.87 mM) |
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 3.5 mg/mL (12.62 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 35.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 3.5 mg/mL (12.62 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 35.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. Solubility in Formulation 3: ≥ 3.5 mg/mL (12.62 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 35.0 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly. Solubility in Formulation 4: 10 mg/mL (36.06 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with ultrasonication. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.6062 mL | 18.0310 mL | 36.0620 mL | |
| 5 mM | 0.7212 mL | 3.6062 mL | 7.2124 mL | |
| 10 mM | 0.3606 mL | 1.8031 mL | 3.6062 mL |