Sulfamonomethoxine is a long acting antibiotic of the sulfonamide class, acting as an inhibitor of dihydropteroate synthetase, thus leading to the blockage of the synthesis of folic acid.
Physicochemical Properties
| Molecular Formula | C11H12N4O3S |
| Molecular Weight | 280.3030 |
| Exact Mass | 280.063 |
| Elemental Analysis | C, 47.14; H, 4.32; N, 19.99; O, 17.12; S, 11.44 |
| CAS # | 1220-83-3 |
| Related CAS # | Sulfamonomethoxine-d4;1286538-12-2;Sulfamonomethoxine sodium;38006-08-5;Sulfamonomethoxine-d3;Sulfamonomethoxine-13C6;1416768-32-5;Sulfamonomethoxine-d3-1;2704162-84-3 |
| PubChem CID | 5332 |
| Appearance | Solid powder |
| Density | 1.3936 |
| Boiling Point | 513℃ |
| Melting Point | 203-206°C |
| Flash Point | >110° |
| Vapour Pressure | 0.0±1.3 mmHg at 25°C |
| Index of Refraction | 1.6200 |
| LogP | -0.04 |
| Hydrogen Bond Donor Count | 2 |
| Hydrogen Bond Acceptor Count | 7 |
| Rotatable Bond Count | 4 |
| Heavy Atom Count | 19 |
| Complexity | 376 |
| Defined Atom Stereocenter Count | 0 |
| SMILES | S(C1C([H])=C([H])C(=C([H])C=1[H])N([H])[H])(N([H])C1=C([H])C(=NC([H])=N1)OC([H])([H])[H])(=O)=O |
| InChi Key | WMPXPUYPYQKQCX-UHFFFAOYSA-N |
| InChi Code | InChI=1S/C11H12N4O3S/c1-18-11-6-10(13-7-14-11)15-19(16,17)9-4-2-8(12)3-5-9/h2-7H,12H2,1H3,(H,13,14,15) |
| Chemical Name | 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide |
| HS Tariff Code | 2934.99.9001 |
| Storage |
Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition | Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs) |
Biological Activity
| References |
[1]. Ryuji Ueno. Pharmacokinetics and Bioavailability of Sulfamonomethoxine in Cultured Eel. Fish Pathology,33(4),297-301,1998.10. [2]. Environ Sci Pollut Res Int. 2014 Jun;21(12):7436-48. |
| Additional Infomation |
Sulfamonomethoxine is a sulfonamide and a member of benzenes. Sulfamonomethoxine is a long-acting sulfonamide antibiotic. Long acting sulfonamide antibacterial agent. |
Solubility Data
| Solubility (In Vitro) |
DMSO : 56~100 mg/mL ( 199.78~356.76 mM) H2O : ~1 mg/mL (~3.57 mM) Ethanol : ~4 mg/mL |
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (8.92 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (8.92 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. Solubility in Formulation 3: 10% DMSO+40% PEG300+5% Tween-80+45% Saline: ≥ 2.5 mg/mL (8.92 mM) (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.5676 mL | 17.8380 mL | 35.6761 mL | |
| 5 mM | 0.7135 mL | 3.5676 mL | 7.1352 mL | |
| 10 mM | 0.3568 mL | 1.7838 mL | 3.5676 mL |