Sulfamonomethoxine is a long acting antibiotic of the sulfonamide class, acting as an inhibitor of dihydropteroate synthetase, thus leading to the blockage of the synthesis of folic acid.

Physicochemical Properties

Molecular Formula	C11H12N4O3S
Molecular Weight	280.3030
Exact Mass	280.063
Elemental Analysis	C, 47.14; H, 4.32; N, 19.99; O, 17.12; S, 11.44
CAS #	1220-83-3
Related CAS #	Sulfamonomethoxine-d4;1286538-12-2;Sulfamonomethoxine sodium;38006-08-5;Sulfamonomethoxine-d3;Sulfamonomethoxine-13C6;1416768-32-5;Sulfamonomethoxine-d3-1;2704162-84-3
PubChem CID	5332
Appearance	Solid powder
Density	1.3936
Boiling Point	513℃
Melting Point	203-206°C
Flash Point	>110°
Vapour Pressure	0.0±1.3 mmHg at 25°C
Index of Refraction	1.6200
LogP	-0.04
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	4
Heavy Atom Count	19
Complexity	376
Defined Atom Stereocenter Count	0
SMILES	S(C1C([H])=C([H])C(=C([H])C=1[H])N([H])[H])(N([H])C1=C([H])C(=NC([H])=N1)OC([H])([H])[H])(=O)=O
InChi Key	WMPXPUYPYQKQCX-UHFFFAOYSA-N
InChi Code	InChI=1S/C11H12N4O3S/c1-18-11-6-10(13-7-14-11)15-19(16,17)9-4-2-8(12)3-5-9/h2-7H,12H2,1H3,(H,13,14,15)
Chemical Name	4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References	[1]. Ryuji Ueno. Pharmacokinetics and Bioavailability of Sulfamonomethoxine in Cultured Eel. Fish Pathology,33(4),297-301,1998.10. [2]. Environ Sci Pollut Res Int. 2014 Jun;21(12):7436-48.
Additional Infomation	Sulfamonomethoxine is a sulfonamide and a member of benzenes. Sulfamonomethoxine is a long-acting sulfonamide antibiotic. Long acting sulfonamide antibacterial agent.

Solubility Data

Solubility (In Vitro)

DMSO : 56~100 mg/mL ( 199.78~356.76 mM) H2O : ~1 mg/mL (~3.57 mM) Ethanol : ~4 mg/mL

Solubility (In Vivo)

Solubility in Formulation 1: ≥ 2.5 mg/mL (8.92 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (8.92 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. Solubility in Formulation 3: 10% DMSO+40% PEG300+5% Tween-80+45% Saline: ≥ 2.5 mg/mL (8.92 mM)  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	3.5676 mL	17.8380 mL	35.6761 mL
	5 mM	0.7135 mL	3.5676 mL	7.1352 mL
	10 mM	0.3568 mL	1.7838 mL	3.5676 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.