Sulfamethazine (Sulfadimidine) sodium is an antibacterial agent that is extensively used in the research and prevention of various animal diseases (such as gastrointestinal and respiratory tract infections). In China and the European Commission, the maximum residue level of sulfamethazine sodium in animal products is 100 µg/kg.

Physicochemical Properties

Molecular Formula	C12H13N4NAO2S
Molecular Weight	300.31
Exact Mass	300.065
CAS #	1981-58-4
Related CAS #	Sulfamethazine;57-68-1;Sulfamethazine-d4;1020719-82-7
PubChem CID	13456556
Appearance	White to off-white solid powder
Density	1.392g/cm3
Boiling Point	526.2ºC at 760mmHg
Melting Point	176ºC
Flash Point	272.1ºC
Vapour Pressure	3.64E-11mmHg at 25°C
LogP	2.997
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	3
Heavy Atom Count	20
Complexity	383
Defined Atom Stereocenter Count	0
SMILES	S(C1C([H])=C([H])C(=C([H])C=1[H])N([H])[H])([N-]C1=NC(C([H])([H])[H])=C([H])C(C([H])([H])[H])=N1)(=O)=O.[Na+]
InChi Key	NGIVTUVVBWOTNT-UHFFFAOYSA-N
InChi Code	InChI=1S/C12H13N4O2S.Na/c1-8-7-9(2)15-12(14-8)16-19(17,18)11-5-3-10(13)4-6-11;/h3-7H,13H2,1-2H3;/q-1;+1
Chemical Name	sodium;(4-aminophenyl)sulfonyl-(4,6-dimethylpyrimidin-2-yl)azanide
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture.
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

Targets	Bacterial[1]
ln Vivo	Sulfamethazine (80 mg/kg; intravenous injection; healthy female pigs) therapy considerably increases t1/2α, Vd, and CIB and significantly reduces α, β, and AUC0->∞. The absolute bioavailability of Sulfamethazine in pigs is 1.01 after a single intramuscular dosage of 80 mg/kg[1].
Animal Protocol	Animal/Disease Models: 19 healthy female pigs (6weeks old, 4.5-6.2 kg)[1] Doses: 80 mg/kg Route of Administration: intravenous (iv)injection (pharmacokinetic/PK study) Experimental Results: The half-life in distribution phase is 0.23 h and half-lifes in eliminations phase is 9.8 h. α, β and the AUC0->∞ were Dramatically diminished and t1 /2α, Vd and CIB were Dramatically increased, and the absolute bioavailability in pigs is 1.01.
References	[1]. VAN Poucke LSG, et al. Pharmacokinetics and Tissue Residues of Sulfathiazole and Sulfamethazine in Pigs. J Food Prot. 1994 Sep;57(9):796-801. [2]. Sheng Y J, et al. Production of chicken yolk IgY to sulfamethazine: comparison with rabbit antiserum IgG. Food and Agricultural Immunology. 2015, 26(3):305-316.
Additional Infomation	Sulfamethazine Sodium is a sodium salt form of sulfamethazine, a sulfonamide antibiotic used in the lifestock industry. See also: Sulfamethazine (has active moiety) ... View More ...

Solubility Data

Solubility (In Vitro)

DMSO : 250 mg/mL (832.47 mM) H2O : 100 mg/mL (332.99 mM)

Solubility (In Vivo)

Solubility in Formulation 1: ≥ 2.08 mg/mL (6.93 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	3.3299 mL	16.6495 mL	33.2989 mL
	5 mM	0.6660 mL	3.3299 mL	6.6598 mL
	10 mM	0.3330 mL	1.6649 mL	3.3299 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.