Stearoylcarnitine is a fatty ester lipid molecule that is an endogenously produced metabolite of the human body. Stearoylcarnitine can serve as a metabolic biomarker for early-onset preeclampsia and late-onset preeclampsia.

Physicochemical Properties

Molecular Formula	C25H49NO4
Molecular Weight	427.660868406296
Exact Mass	427.366
CAS #	25597-09-5
PubChem CID	52922056
Appearance	White to off-white solid powder
LogP	8.8
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	21
Heavy Atom Count	30
Complexity	426
Defined Atom Stereocenter Count	1
SMILES	O(C(CCCCCCCCCCCCCCCCC)=O)[C@H](CC(=O)[O-])C[N+](C)(C)C
InChi Key	FNPHNLNTJNMAEE-HSZRJFAPSA-N
InChi Code	InChI=1S/C25H49NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h23H,5-22H2,1-4H3/t23-/m1/s1
Chemical Name	(3R)-3-octadecanoyloxy-4-(trimethylazaniumyl)butanoate
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

ln Vivo	In first-trimester (11–14 weeks of gestation) pregnant women, serum levels of Stearoylcarnitine were significantly lower in those who later developed preeclampsia compared to women with normal pregnancies [1] As a potential metabolic marker for preeclampsia prediction, Stearoylcarnitine exhibited certain diagnostic performance, with a measurable area under the receiver operating characteristic curve (AUC) when used alone for preeclampsia screening [1]
References	[1]. First-Trimester Serum Acylcarnitine Levels to Predict Preeclampsia: A Metabolomics Approach. Dis Markers. 2015;2015:857108.
Additional Infomation	O-octadecanoyl-L-carnitine is an O-acyl-L-carnitine in which the acyl group is specified as stearoyl (octadecanoyl). It has a role as a human metabolite. It is a saturated fatty acyl-L-carnitine and a long-chain fatty acyl-L-carnitine. It is functionally related to an octadecanoic acid. Stearoylcarnitine is a long-chain acylcarnitine involved in fatty acid metabolism [1] Literature [1] focused on its serum levels in the first trimester via a metabolomics approach to identify potential predictive markers for preeclampsia [1] The experimental workflow included: collecting serum samples from pregnant women at 11–14 weeks of gestation, sample pretreatment (e.g., protein precipitation, derivatization), detecting Stearoylcarnitine concentration using liquid chromatography-mass spectrometry (LC-MS), statistically comparing levels between preeclampsia and normal control groups, and evaluating its predictive efficacy [1] The study did not investigate the pharmacological activity, molecular targets, toxicity, or pharmacokinetics of Stearoylcarnitine [1]

Solubility Data

Solubility (In Vitro)

DMSO : ~7.14 mg/mL (~16.70 mM) H2O : < 0.1 mg/mL

Solubility (In Vivo)

Solubility in Formulation 1: ≥ 2.5 mg/mL (5.85 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (5.85 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. Solubility in Formulation 3: ≥ 2.5 mg/mL (5.85 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly. Solubility in Formulation 4: 50 mg/mL (116.92 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with ultrasonication.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	2.3383 mL	11.6915 mL	23.3831 mL
	5 mM	0.4677 mL	2.3383 mL	4.6766 mL
	10 mM	0.2338 mL	1.1692 mL	2.3383 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.