Stearic acid-d3 is the deuterated form of Stearic acid. Stearic acid is a long-chain dietary saturated fatty acid found in many animal and vegetable oils and fats.

Physicochemical Properties

Molecular Formula	C18H33D3O2
Molecular Weight	287.50
Exact Mass	287.29
CAS #	62163-39-7
Related CAS #	Stearic acid;57-11-4
PubChem CID	16213464
Appearance	White to off-white solid powder
Density	0.897g/cm3
Boiling Point	361ºC(lit.)
Melting Point	68-70ºC(lit.)
Flash Point	162.4ºC
Index of Refraction	1.455
LogP	6.332
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	16
Heavy Atom Count	20
Complexity	202
Defined Atom Stereocenter Count	0
SMILES	[2H]C([2H])([2H])CCCCCCCCCCCCCCCCC(=O)O
InChi Key	QIQXTHQIDYTFRH-FIBGUPNXSA-N
InChi Code	InChI=1S/C18H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h2-17H2,1H3,(H,19,20)/i1D3
Chemical Name	18,18,18-trideuteriooctadecanoic acid
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment (e.g. under nitrogen), avoid exposure to moisture and light.
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

ln Vitro	Drug compounds have included stable heavy isotopes of carbon, hydrogen, and other elements, mostly as quantitative tracers while the drugs were being developed. Because deuteration may have an effect on a drug's pharmacokinetics and metabolic properties, it is a cause for concern [1].
References	[1]. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Dietary stearic acid leads to a reduction of visceral adipose tissue in athymic nude mice. PLoS One. 2014 Sep 15;9(9):e104083.
Additional Infomation	Stearic acid(d3) is a long-chain fatty acid and a deuterated fatty acid.

Solubility Data

Solubility (In Vitro)

DMSO: 12.5 mg/mL (43.48 mM)

Solubility (In Vivo)

Solubility in Formulation 1: ≥ 1.25 mg/mL (4.35 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 12.5 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	3.4783 mL	17.3913 mL	34.7826 mL
	5 mM	0.6957 mL	3.4783 mL	6.9565 mL
	10 mM	0.3478 mL	1.7391 mL	3.4783 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.