Sodium iodoacetate is a specific inhibitor of GAPDH. It can induce articular cartilage damage (OA).

Physicochemical Properties

Molecular Formula	C2H2INAO2
Molecular Weight	207.93
Exact Mass	207.899
CAS #	305-53-3
PubChem CID	5239
Appearance	Solid powder
Boiling Point	262.1ºC at 760mmHg
Melting Point	208 °C (dec.)(lit.)
Flash Point	112.3ºC
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	1
Heavy Atom Count	6
Complexity	46.8
Defined Atom Stereocenter Count	0
SMILES	C(=O)([O-])CI.[Na+]
InChi Key	AGDSCTQQXMDDCV-UHFFFAOYSA-M
InChi Code	InChI=1S/C2H3IO2.Na/c3-1-2(4)5;/h1H2,(H,4,5);/q;+1/p-1
Chemical Name	sodium;2-iodoacetate
Synonyms	Iodoacetic acid sodium salt
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment (e.g. under nitrogen), avoid exposure to moisture and light.
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References	[1]. Xu, Y. et al. Glycolysis in Innate Immune Cells Contributes to Autoimmunity. Frontiers in Immunology, 13. [2]. Soluble CCR2 gene therapy controls joint inflammation, cartilage damage, and the progression of osteoarthritis by targeting MCP-1 in a monosodium iodoacetate (MIA)-induced OA rat model. Journal of Translational Medicine, 20(1)
Additional Infomation	A derivative of ACETIC ACID that contains one IODINE atom attached to its methyl group.

Solubility Data

Solubility (In Vitro)	DMSO : 100 mg/mL (480.93 mM; with sonication) H2O : ≥ 100 mg/mL (480.93 mM)
Solubility (In Vivo)	Solubility in Formulation 1: ≥ 100 mg/mL (480.93 mM)(Saturation unknown) in Saline (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution, *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	4.8093 mL	24.0466 mL	48.0931 mL
	5 mM	0.9619 mL	4.8093 mL	9.6186 mL
	10 mM	0.4809 mL	2.4047 mL	4.8093 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.