Salifungin (also known as Bromochlorosalicylanilide; Multifungin) is a novel and potent antifungal agent and may cause allergic contact dermatitis in some individuals.

Physicochemical Properties

Molecular Formula	C13H9BRCLNO2
Molecular Weight	326.5731
Exact Mass	324.951
CAS #	3679-64-9
PubChem CID	77254
Appearance	White to off-white solid powder
Density	1.675g/cm3
Boiling Point	372.8ºC at 760mmHg
Melting Point	246ºC
Flash Point	179.3ºC
Index of Refraction	1.699
LogP	4.133
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	2
Heavy Atom Count	18
Complexity	295
Defined Atom Stereocenter Count	0
InChi Key	QBSGXIBYUQJHMJ-UHFFFAOYSA-N
InChi Code	InChI=1S/C13H9BrClNO2/c14-8-1-6-12(17)11(7-8)13(18)16-10-4-2-9(15)3-5-10/h1-7,17H,(H,16,18)
Chemical Name	5-Bromo-4'-chlorosalicylanilide
Synonyms	Salifungin; Bromosalicylchloranilide; Multifungin
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: This product requires protection from light (avoid light exposure) during transportation and storage.
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

Targets	candidiasis
References	[1]. Czas Stomatol. 1983 Apr;36(4):313-5. [2]. Zentralbl. Mikrobiol. 148 (1993),549-557. [3]. Contact Dermatitis.1986 May;14(5):319.
Additional Infomation	Bromochlorosalicylanilide is a member of benzamides. See also: Multifungin (annotation moved to).

Solubility Data

Solubility (In Vitro)

DMSO : 65~250 mg/mL ( 199.03~765.53 mM ) Ethanol : ~5 mg/mL

Solubility (In Vivo)

Solubility in Formulation 1: ≥ 2.08 mg/mL (6.37 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.08 mg/mL (6.37 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly. Solubility in Formulation 3: 10% DMSO+40% PEG300+5% Tween-80+45% Saline: ≥ 2.08 mg/mL (6.37 mM)  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	3.0621 mL	15.3107 mL	30.6213 mL
	5 mM	0.6124 mL	3.0621 mL	6.1243 mL
	10 mM	0.3062 mL	1.5311 mL	3.0621 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.