STING agonist-8 diHCl (5-AB) is a potent STING agonist with EC50 of 27 nM in THP1-Dual KI-hSTING-R232 cells.

Physicochemical Properties

Molecular Formula	C41H48CL2N14O4
Molecular Weight	871.82
Related CAS #	STING agonist-8;2745723-90-2
Appearance	White to off-white solid powder
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture.
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. Heterocyclic compounds as sting modulators. WO2021239068A1.

Solubility Data

Solubility (In Vitro)

DMSO :~5 mg/mL (~5.74 mM)

Solubility (In Vivo)

Solubility in Formulation 1: ≥ 1 mg/mL (1.15 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 10.0 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	1.1470 mL	5.7351 mL	11.4703 mL
	5 mM	0.2294 mL	1.1470 mL	2.2941 mL
	10 mM	0.1147 mL	0.5735 mL	1.1470 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.