SPB is the active molecular linker of ADC. It is connected to Xanthotoxol through the ADC linker and exhibits anti-inflammatory effect.

Physicochemical Properties

Molecular Formula	C19H15NO8
Molecular Weight	385.324305772781
Exact Mass	385.079
CAS #	858128-57-1
PubChem CID	15950836
Appearance	Light yellow to yellow solid powder
LogP	1.2
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	8
Rotatable Bond Count	7
Heavy Atom Count	28
Complexity	688
Defined Atom Stereocenter Count	0
SMILES	O=C1C=CC2C(=C(C3=C(C=2)C=CO3)OCCCC(ON2C(=O)CCC2=O)=O)O1
InChi Key	ZOMXGWWLJXRQKZ-UHFFFAOYSA-N
InChi Code	InChI=1S/C19H15NO8/c21-13-4-5-14(22)20(13)28-16(24)2-1-8-25-19-17-12(7-9-26-17)10-11-3-6-15(23)27-18(11)19/h3,6-7,9-10H,1-2,4-5,8H2
Chemical Name	(2,5-dioxopyrrolidin-1-yl) 4-(7-oxofuro[3,2-g]chromen-9-yl)oxybutanoate
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

Solubility Data

Solubility (In Vitro)

DMSO : 50 mg/mL (129.76 mM)

Solubility (In Vivo)

Solubility in Formulation 1: ≥ 2.5 mg/mL (6.49 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	2.5952 mL	12.9762 mL	25.9525 mL
	5 mM	0.5190 mL	2.5952 mL	5.1905 mL
	10 mM	0.2595 mL	1.2976 mL	2.5952 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.